IDRPublicationList

List of publications that report use of an Integrated Data Repository (IDR). ("IDR success stories")

True positive

• ROSIGLITAZONE and claims study - Nationwide, observational, retrospective, inception cohort of 227,571 Medicare beneficiaries aged 65 years or older (mean age, 74.4 years) who initiated treatment with rosiglitazone or pioglitazone through a Medicare Part D prescription drug plan from July 2006-June 2009 and who underwent follow-up for up to 3 years after thiazolidinedione initiation.
  • Graham DJ et al. Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone. JAMA doi:10.1001/jama.2010.920 http://www.ncbi.nlm.nih.gov/pubmed/20584880
    • • http://en.wikipedia.org/wiki/Rosiglitazone

• CIMETIDINE and drug repurposing. Database finding lead to a mouse model (confirmed effect) (clinical trial started [documentation missing]
  • cimetidine and lung cancer http://www.ncbi.nlm.nih.gov/pubmed/21849665

• thanks to this IDR, we were able to complete this trial (anecdotal)

False positive

Example of a published findings in an IDR that later turned out to be false. E.g., reporting an effect of a drug (or other findings) from an IDR analysis, but later human trials or other experiments did not validate it.

• tbd

See Also

• CIDR