Difference between revisions of "Lab on a Chip"
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Lab on a Chip is a form of micro-analytic processing referred to as microfluidics - a form of engineered fluid management on a micro scale which promises to improve diagnostics and research. These techniques are also referred to as "miniaturized total analytic systems" or µTAS. These techniques were first developed by the semi-conductor industry and later expanded by the micro-electromechanical systems field. <ref name="first">Sackmann EK, Fulton AL, Beebe DJ. The present and future role of microfluidics in biomedical research. Nature. 2014 Mar 13;507(7491):181–9.</ref> | Lab on a Chip is a form of micro-analytic processing referred to as microfluidics - a form of engineered fluid management on a micro scale which promises to improve diagnostics and research. These techniques are also referred to as "miniaturized total analytic systems" or µTAS. These techniques were first developed by the semi-conductor industry and later expanded by the micro-electromechanical systems field. <ref name="first">Sackmann EK, Fulton AL, Beebe DJ. The present and future role of microfluidics in biomedical research. Nature. 2014 Mar 13;507(7491):181–9.</ref> | ||
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+ | Microfluidic assays may ultimately end with a visual end-point. The first visual assays were chemotactic studies, monitoring the migration of cells toward a chemoattractant. | ||
== Use == | == Use == |
Revision as of 00:06, 27 October 2014
Contents
History
Lab on a Chip is a form of micro-analytic processing referred to as microfluidics - a form of engineered fluid management on a micro scale which promises to improve diagnostics and research. These techniques are also referred to as "miniaturized total analytic systems" or µTAS. These techniques were first developed by the semi-conductor industry and later expanded by the micro-electromechanical systems field. [1]
Microfluidic assays may ultimately end with a visual end-point. The first visual assays were chemotactic studies, monitoring the migration of cells toward a chemoattractant.
Use
Advantages
The advantages of Lab on a Chip microfluidic processing are: to reduce the sample volume substantially; to reduce the cost of reagents and maximize information gleaned from precious samples; to provide gains in scalability for screening applications and batch sample processing analogous to multi-well plates; and to provide the investigator with substantially more control and predictability of the spatio-temporal dynamics of the cell microenvironment.[1]
These devices are capable of performing qualitative and quantitative analyses without the need for equipment with a large footprint. More specifically, with further development, microfluidics holds the promise of providing the capability to perform analyses in context-specific settings without the need for large sample volumes nor the wait for determination. Lab on a Chip, as a platform, could become a major component in the further development of wearable devices, coupled to devices for connectivity, capable of communicating with personal health records or in an institutional setting, with electronic healthcare records.