Difference between revisions of "Potentially Inappropriate Medications for Older Adults: 65 and Older - Independent of Diagnoses or Conditions - Based on 2000 Upated Beers Criteria (drugs with ADE severity rating of HIGH only)"

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==Potentially Inappropriate Medications for Older Adults: 65 and Older - Independent of Diagnoses or Conditions - Based on 2000 Upated Beers Criteria==
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#REDIRECT [[CDS]]
 
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'''''[[:Potentially_Inappropriate_Medication_%28PIM%29_Use_in_Older_Adults:_65_and_Older_-_Independent_of_Diagnoses_or_Conditions_-_Based_on_Upated_Beers_Criteria|Also See Upated Beers Criteria]]'''''
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----
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'''''Back to'''''
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[[:CDS|CDS]]
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[[:CDS#Medication-Based_Safety_Rules|Medication-Based Safety Rules]]
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----
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The list of drugs and drug-classes below have Concerns that Marked with '''''HIGH''''' in regard to prescribe to Older Adults: 65 and Older Based on 2000 Updated and revised Beers Criteria Independent of Diagnoses or Conditions.
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The following rule is derived for the medications below:
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'''Assumptions and conditions'''
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-- Based on 2000 Updated and revised Beers Criteria
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-- Drugs or Drug-Classes utilized by the rule are the "Generic" names
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-- Some Drugs are no longer in use
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-- All Drugs below are marked with HIGH Concern
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-- The patient has no other conditions beside the one intended to be treated with the drugs below
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'''The Rule'''
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Event Prescribe new drug OR Add new drug OR Change current Drug
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'''Conditions'''
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If the patient is male or female and is 65 years or older
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And
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If the patient has no other conditions
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And
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If the drug being prescribed is from the list below
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And
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If patient has no allergy to this drug
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And
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If patient have no other drugs that are contradicting to this drug
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And
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If the drug is dose Independent
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And
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If the drug is dose dependent and the dose intended is matching the dose listed in the table
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Then
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The Drug has a marked with HIGH Concern and the decision should be re-evaluated.----
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----
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=='''Drugs By Generic Name'''==
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===Amiodarone===
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'''Drug Name (Generic)'''    : Amiodarone
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'''Drug Name (Brand Name)'''   : Cordarone
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'''Dose Dependent'''         : No
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'''Doses, Exceptions & Other'''  : NA
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'''Concerns and Rules'''   : Associated with QT interval problems and risk of provoking torsades depointes.
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Lack of efficacy in older adults.
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----
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===Amitriptyline===
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'''Drug Name (Generic)'''    : Amitriptyline
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'''Drug Name (Brand Name)'''   : Elavil
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'''Dose Dependent'''         : No
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'''Doses, Exceptions & Other'''  : NA
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'''Concerns and Rules'''   : Because of its strong anticholinergic and sedation properties, amitriptyline is
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rarely the antidepressant of choice for elderly patients.
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----
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===Chlordiazepoxide-amitriptyline===
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'''Drug Name (Generic)'''    : Chlordiazepoxide-amitriptyline
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'''Drug Name (Brand Name)'''   : Limbitrol
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'''Dose Dependent'''         : No
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'''Doses, Exceptions & Other'''  : NA
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'''Concerns and Rules'''   : Because of its strong anticholinergic and sedation properties, amitriptyline is
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rarely the antidepressant of choice for elderly patients.
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----
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===Chlorpropamide===
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'''Drug Name (Generic)'''    : Chlorpropamide
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'''Drug Name (Brand Name)'''   : Limbitrol
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'''Dose Dependent'''         : No
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'''Doses, Exceptions & Other'''  : NA
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'''Concerns and Rules'''   : It has a prolonged half-life in elderly patients and could cause prolonged
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hypoglycemia. Additionally, it is the only oral hypoglycemic agent that causes (SIADH:syndrome of inappropriate
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antidiuretic hormone secretionl).
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----
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=='''Drugs By Drug-Class'''==
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===Amphetamines and Amphetamines agents===
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'''Drug Class'''            : Amphetamines and Amphetamines agents
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'''Dose Dependent'''           : No
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'''Doses, Exceptions & Other''' : Excluding Methylphenidate hydrochloride and Anorexics
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'''Concerns and Rules'''   : These drugs have potential for causing dependence, hypertension, angina, and
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myocardial infarction. And (CNS:central nervous system) stimulant adverse effects.
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----
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===Anorexic agents===
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'''Drug Class'''            : Anorexic agents
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'''Dose Dependent'''           : No
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'''Doses, Exceptions & Other''' : NA
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'''Concerns and Rules'''   : These drugs have potential for causing dependence, hypertension, angina, and
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myocardial infarction.                         
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----
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===Anticholinergics and antihistamines===
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'''Drug Class'''            : Anticholinergics and antihistamines
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'''Dose Dependent'''           : No
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'''Doses, Exceptions & Other''' : NA
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'''Concerns and Rules'''   : All nonprescription and many prescription antihistamines may have potent
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anticholinergic properties. Nonanticholinergic antihistamines are preferred in elderly patients when treating
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allergic reactions.
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'''List of Drugs in this Class are'''
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''"Drug Generic Name:Drug Brand Name"''
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'''Hydroxyzine''':Atarax
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'''Diphenhydramine''':Benadryl
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'''Chlorpheniramine''':Chlor-Trimeton
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'''Cyproheptadine''':Periactin
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'''Promethazine''':Phenergan
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'''Dexchlorpheniramine''':Polaramine
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'''Tripelennamine''':Tripelennamine
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'''Hydroxyzine''':Vistaril
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----
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===Barbiturates===
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'''Drug Class'''            : Barbiturates
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'''Dose Dependent'''           : No
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'''Doses, Exceptions & Other''' : All type except phenobarbital Except when used to control seizures.
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'''Concerns and Rules'''   : Are highly addictive and cause more adverse effects than most sedative or
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hypnotic drugs in elderly patients.
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----
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===Benzodiazepines===
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'''Drug Class'''            : Benzodiazepines
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'''Dose Dependent'''           : Yes
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'''Doses, Exceptions & Other''' : Doses of short-acting
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'''Concerns and Rules'''   : Because of increased sensitivity to benzoadiazepines in elderly patients,
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smaller doses may be effective as well as safer. Total daily doses should rarely exceed the suggested maximums.
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'''List of Drugs in this Class are'''
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''"Drug Generic Name:Drug Brand Name"''
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'''Lorazepam''':Ativan  For doses greater than 3 mg
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'''Triazolam''':Halcion  For doses greater than 0.25 mg
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'''Temazepam''':Restoril For doses greater than 15 mg
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'''Oxazepam''':Serax    For doses greater than 60 mg
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'''Llprazolam''':Xanax  For doses greater than 2 mg
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----
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'''''Back to'''''
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[[:CDS|CDS]]
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[[:CDS#Medication-Based_Safety_Rules|Medication-Based Safety Rules]]
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----
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==References==
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[http://archinte.ama-assn.org/cgi/content/full/163/22/2716 Donna M. Fick, PhD, RN, et al. Updating the Beers Criteria for Potentially Inappropriate Medication Use in Older Adults:Results of a US Consensus Panel of Experts. Archives of Internal Medicine. 2003;163:2716-2724]
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----
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'''Aiman Alrawabdeh 5/28/2006'''
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----
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[[Category:OHSU-SP-06]]
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[[Category:CDS]]
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[[Category:Medication-Based Safety Rules]]
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Latest revision as of 21:29, 16 November 2011